VNUHCM-US has been serving as a pioneer in offering various scientific degrees across Southern Vietnam since its original establishment as the Indochina College of Science in 1941.

 

In 1977, thanks to the country reunification, the Faculty of Science was merged with the Faculty of Letters to establish the Ho Chi Minh City University.

Due to some internal reforms, at the beginning of 1996, the Faculty of Science became the University of Natural Sciences -  one of the five affiliated universities of the Vietnam National University Ho Chi Minh City. In 2007, the University was officially renamed as the University of Science.

Since 2007 to present, VNUHCM – US is one of the public universities which plays a particularly important role in offering education and scientific research within VNUHCM system.